BPS1021 · Medicinal chemistry 1: Structure

Overview

This unit introduces you to the principles of molecular structure that determine the chemical properties and mechanism of action of therapeutic agents. After examining how the rules of chemical bonding and molecular shape derive from the electronic structure of atoms, the unit will explore how these rules lead to the complex architecture of organic chemistry and to patterns of molecular reactivity. This will involve a discussion of the following topics: • Hydrocarbons (alkanes, alkenes, alkynes) • Haloalkanes • Chirality • Alcohols, ethers and thiols • Aromatic compounds (benzene and its derivatives) Analytical methods (spectrophotometry, NMR and IR spectroscopy) to identify molecules and their structural features will be introduced in theory and practice. In laboratory classes, you will learn how to harness molecular reactivity for the preparation of medicinal compounds using common organic chemical techniques.

Offerings

Assessment

The Handbook lists an examination for this unit.

Final assessment: 40%; in-semester assessment: 60%.

Assessment details may change. Please refer to the assessment information in Moodle closer to the start of the teaching period.

Requisites

The Handbook lists no prerequisite, corequisite or prohibition for this unit.

Learning outcomes

1. Apply the key concepts in chemical structure and bonding, including functional groups, to rationalising the shape, properties and reactions of molecules;
2. Determine the identity and molecular structure of small molecules using spectroscopic, chromatographic and other experimental data.
3. Safely and competently perform a basic practical investigation using standard laboratory techniques.

Workload

• Thirteen 1-hour online preparation modules (Discovery) • Twenty 1-hour online interactive modules • Twelve 1-hour scheduled Q&A sessions • Six 3-hour laboratories • Six 3-hour scheduled workshops • Two hours of scheduled assessments • Sixty hours of independent study

Student experience, not official rules. Nothing here changes what the Handbook says.