BPS3041 · Synthetic chemistry 2: Advanced methods

Overview

The principal aim of this unit is to provide you with a detailed knowledge of numerous aspects of synthetic organic chemistry, as it applies to modern medicinal chemistry. The subject follows from BPS2021, covering advanced organic synthesis and methodology. Topics include catalysis in synthesis, radical chemistry, organometallic chemistry, heterocyclic chemistry, reactive intermediates and stereochemistry, as well as retrosynthetic analysis. An understanding of reaction mechanisms will be emphasized throughout. The laboratory component reinforces aspects of the lecture course with laboratory experience. This will involve: • catalysis and biocatalysis • organometallic reactions • radical reactions • heterocyclic chemistry • stereoselective synthesis • pericyclic reactions • reactive intermediates

Offerings

Assessment

The Handbook lists an examination for this unit.

In-semester assessment 50%, final assessment 50%

Assessment details may change. Please refer to the assessment information in Moodle closer to the start of the teaching period.

Requisites

The Handbook lists no prerequisite, corequisite or prohibition for this unit.

Learning outcomes

1. Explain key concepts in catalysis, radical reactions, organometallic and heterocyclic chemistry and apply them to problems in synthetic chemistry.
2. Undertake a retrosynthetic analysis and design a synthesis of a target molecule;
3. Read and understand the synthetic organic chemistry literature;
4. Safely and competently perform a routine synthesis and carry out the most common operations in a synthetic chemistry laboratory.
5. Apply appropriate problem-solving approaches to questions in synthesis planning and execution .

Workload

• Twelve 1-hour online discovery modules • Twenty-four 1-hour online modules • Twelve 2-hour Workshops • Six 4-hour Laboratories • Eleven 2-hour Applied sessions • One hour of scheduled mid-semester assessment • Two hours of scheduled final assessment

Student experience, not official rules. Nothing here changes what the Handbook says.