BPS1012 · Human physiology 2: Body systems

Overview

This unit builds and extends on concepts learnt in BPS1011 Human Physiology I: Cells to systems. This unit extends on a foundation of knowledge about mammalian systems and the relationship between pathophysiology and the rational design and use of drugs. You will investigate the physiological basis of disease, highlighting the causal connections between cell biochemistry, body function at the tissue, organ and system-level and human health. Several cells, tissues, organs and systems will be analysed in detail, and examples of disease states amenable to pharmacotherapy will be discussed. The unit aims to provide a basic understanding of the functions of organs and systems such as the cardiovascular and respiratory systems; however, there is an equal emphasis on one of the key components of drug discovery: the choice of therapeutic target based on a thorough understanding of mechanism of action of drugs. A primary aim of this unit is to provide you with an understanding of basic pharmacological principles and how these are applied in pharmaceutical science. You will undertake experimental approaches designed to solve biochemical, physiological and pharmacological research questions. Topics to be covered include the: • fundamentals of drug action • cardiovascular system • respiratory system • pathophysiology of human disease states

Offerings

Assessment

The Handbook lists an examination for this unit.

In-semester assessment 60%; final assessment: 40%.

Assessment details may change. Please refer to the assessment information in Moodle closer to the start of the teaching period.

Requisites

The Handbook lists no prerequisite, corequisite or prohibition for this unit.

Learning outcomes

1. Describe the structure and function of each major cell, tissue, organ and organ system considered within the unit;
2. Explain how ligands interact with protein targets, such as receptors and enzymes;
3. Compare (evaluate, characterise) pharmaceutical agents based on quantitative and qualitative parameters (affinity, potency, efficacy, etc.)
4. Compare and contrast agonists and antagonists and describe how their characteristics and behaviour can be measured;
5. Analyse and predict the effects observed within a cell, and the impact on cellular function following activation of specific receptor families and receptor (sub)types;
6. Analyse selected disorders and disease states using an understanding of the physiological basis of the disease;
7. Practice basic laboratory techniques and communicate experimental findings;
8. Research a contentious topic in the area of physiology, and debate and communicate the findings of such research, at an appropriate scientific level.

Workload

• Twelve 2-hour online preparation modules (Discovery) • One 2-hour applied session • Six 3-hour laboratories • Six 2-hour workshops • Three 1-hour assessments (progress tests)

Student experience, not official rules. Nothing here changes what the Handbook says.